Enormous Sessile Villous Adenoma (3 of 3)

Villous Adenoma, after spraying methilene blue.

Adenomas are believed to have an abnormal process of cell
proliferation and apoptosis. The proliferative component is not confined to the crypt base and accumulates onto the
surface and infolds downward. In villous adenomas, mesenchymal proliferation results in longer projections and larger polyps.
Epidemiological studies provide evidence of adenoma-to-carcinoma progression. The mean age of adenoma diagnosis is 10 years earlier than with carcinoma, and progression to carcinoma takes a minimum of 4 years.