Duodenal Lymphoma 4 of 24

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This lesion is seen at the end of the fourth portion of the
duodenum bordering the Treitz angle.
In 1993, Wotherspoon and colleagues, described the remarkable observation of regression of marginal zone B -cell lymphoma upon eradication of H pylori using antibiotics. Since then, multiple other medical centers have reported the same phenomenon, with response rates ranging from 60% to 90%.
The interval to histologic regression may be prolonged, with a range of 1 to 25 months and a median of 5 months.
Features associated with failure of regression include a component of large B-cell lymphoma, invasion beyond the submucosa, spread beyond the stomach, and chromosomal abnormalities, such as t and t. In cases that are histologically negative for lymphoma following H pylori eradication, clonal B cells can be detected by polymerase chain reaction up to several years later.

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Julio Murra-Saca

Physician (Internal medicine - Gastroentrology)

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